Hello Bio/(R,S)-CHPG sodium salt/HB0034/50mg
商品编号：
HB0034-50mg
品牌：
hellobio
市场价：
¥3627.00
美元价：
2790.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name(R,S)-CHPGsodiumsalt
- ShortdescriptionSelectivemGluR5agoNIST.Watersolublesodiumsalt.
- BIOLOGicaldescription
SelectivemGlu5receptoragonistwhichshowsnoactivityatmGlu1.PotentiatesNMDA-induceddepolarizationsinrathippocampalslices.Activeinvivo.Watersolublesodiumsalt.
CHPGalsoavailable.
- BiologicalactionAgonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)aceticacidsodiumsalt
- MolecularWeight223.59
- Chemicalstructure
![(R,S)-CHPG sodium salt [1303993-73-8]](images/hellobio/201710/hb0034.png "(R,S)-CHPG sodium salt [1303993-73-8]")
- MolecularFormulaC8H7ClNNaO3
- CASNumber1303993-73-8
- PubChemidentifier52974246
- SMILESC1=CC(=C(C=C1O)C(C(=O)[O-])N)Cl.[Na+]
- SourceSynthetic
- InChi1S/C8H8ClNO3.Na/c9-6-2-1-4(11)3-5(6)7(10)8(12)13;/h1-3,7,11H,10H2,(H,12,13);/q;+1/p-1
- InChiKeyKZRZZIISUUINJT-UHFFFAOYSA-M
- AppearanceBrownsolid
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewSolubleinwater(75mM)andinDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor(R,S)-CHPGsodiumsalt
(RS)-2-chloro-5-hydroxyphenylglycine(CHPG)activatesmGlu5,butnomGlu1,receptorsexpressedinCHOcellsandpotentiatesNMDAresponsesinthehippocampus.
DohertyAJetal(1997)Neuropharmacology36(2):265-7.PubMedID:9144665ActivationofmGluR5attenuatesNMDA-inducedneurotoxicitythroughdisruptionoftheNMDAR-PSD-95complexandpreservationofmitochondrialfunctionindifferentiatedPC12cells.
DaiSHetal(2014)IntJMolSci15(6):10892-907.PubMedID:24941251TheselectivemGluR5agonistCHPGprotectsagainsttraumaticbraininjuryinvitroandinvivoviaERKandAktpathway.
ChenTetal(2012)IntJMolMed29(4):630-6.PubMedID:22211238CharacterisationoftheactionsofgroupImetabotropicglutamatereceptorsubtypeselectiveligandsonexcitatoryaminoacidreleaseandsodium-dependentre-uptakeinratcerebrocorticalminislices.
FazalAetal(2003)JNeuRochem86(6):1346-58.PubMedID:12950444
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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