Hello Bio/CDPPB/HB0175/10mg
商品编号：
HB0175-10mg
品牌：
hellobio
市场价：
¥1326.00
美元价：
1020.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCDPPB
- ShortdescriptionSelectivemGlu5positiveallostericmodulator
- BIOLOGicaldescriptionSelectivemGlu5receptorpositiveallostericmodulator(EC50=27nMforhumanmGlu5receptor).Showsanti-psychoticandcognitiveenhancingactions.Blood-brainbarrierpermeable.
- BiologicalactionPAM
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
- MolecularWeight364.4
- Chemicalstructure
![CDPPB [781652-57-1]](images/hellobio/201710/hb0175.png "CDPPB [781652-57-1]")
- MolecularFormulaC23H16N4O
- CASNumber781652-57-1
- PubChemidentifier11245456
- SMILESC1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4
- InChiInChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
- InChiKeyBKUIZWILNWHFHD-UHFFFAOYSA-N
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(75mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCDPPB
Anovelselectivepositiveallostericmodulatorofmetabotropicglutamatereceptorsubtype5hasinvivoactivityandantipsychotic-likeeffectsinratbehavioralmodels.
KinneyGGetal(2005)JPharmacolExpTher313(1):199-206.PubMedID:15608073Effectsofametabotropicglutamatereceptor5positiveallostericmodulator,CDPPB,onspatiallearningtaskperformanceinrodents.
FowlerSWetal(2013)NeurobiolLearnMem99:25-31.PubMedID:23137441DifferentialeffectsofthemGluR5positiveallostericmodulatorCDPPBinthecortexandstriatumfollowingrepeatedadmiNISTration.
Parmentier-BatteurSetal(2012)Neuropharmacology62(3):1453-60.PubMedID:21112344
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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