您好Bio/（±；）-托架K 8644/HB1209/10mg
商品编号：
HB1209-10mg
品牌：
hellobio
市场价：
¥1794.00
美元价：
1380.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name(±)-BayK8644
- ShortdescriptionL-typeCa2+channelagoNIST.AidsiPSCsgenerationfromMouseembryonicfibroblasts.
- BIOLOGicaldescriptionL-typeCa2+channelagonist.Causesreducedinotropyinthemyocardium.Alsoaidsinducedpluripotentstemcellgenerationfrommouseembryonicfibroblasts(MEFs).Showsconvulsiveandvasoconstrictiveactions.
- BiologicalactionAgonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylicacid,methylester
- MolecularWeight356.3
- Chemicalstructure
![(±)-Bay K 8644 [71145-03-4]](images/hellobio/201710/hb1209.png "(±)-Bay K 8644 [71145-03-4]")
- MolecularFormulaC16H15F3N2O4
- CASNumber71145-03-4
StoringandUsingYourProduct
- Storageinstructions+4°C
- Solubilityoverviewsolubleinethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor(±)-BayK8644
ReducedeffectsofBAYK8644onL-typeCa2+currentinfailinghumancardiacmyocytesarerelatedtoabnormaladrenergicregulation.
ChenXetal(2008)AmJPhysiolHeartCircPhysiol294(5):H2257-67.PubMedID:18359894ActivationofproteinkinaseCby1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-pyridinecarboxylicacidmethylester(BayK8644),acalciumchannelagonist,inalveolartypeIIcells.
SenNetal(1997)BiochemPharmacol53(9):1307-13.PubMedID:9214691DimemorfanpreventsseizuresinducedbytheL-typecalciumchannelactivatorBAYk-8644inmice.
ShinEJetal(2004)BehavBrainRes151(1-2):267-76.PubMedID:15084442
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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