你好Bio/A 769662/HB1351/10mg
商品编号：
HB1351-10mg
品牌：
hellobio
市场价：
¥1891.50
美元价：
1455.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameA769662
- ShortdescriptionPotent,reversIBLeAMPKactivator.InhibitsMSCproliferation.
- BIOLOGicaldescriptionPotentreversibleAMP-activatedproteinkinase(AMPK)activator(EC50=0.8µM).ActivatesAMPKallostericallyandinhibitsAMPKdephosphorylation.AlsoNa+-K+-ATPaseinhibitor(IC50valuesare57and220µMforratandhumanrespectively).Stimulatesglucoseuptakeanddecreasesfattyacidsynthaselevels.AdditionallyshowntoinhibitMSCproliferation.
- BiologicalactionActivator
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6,7-Dihydro-4-hydroxy-3-(2"-hydroxy[1,1"-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
- MolecularWeight360.39
- Chemicalstructure
![A 769662 [844499-71-4]](images/hellobio/201710/hb1351.png "A 769662 [844499-71-4]")
- MolecularFormulaC20H12N2O3S
- CASNumber844499-71-4
- PubChemidentifier54708532
- SMILESC1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
- InChiInChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
- InChiKeyCTESJDQKVOEUOY-UHFFFAOYSA-N
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforA769662
IdentificationandcharacterizationofasmallmoleculeAMPKactivatorthattreatskeycomponentsoftype2diabetesandthemetabolicsyndrome.
CoolBetal(2006)CellMetab3(6):403-16.PubMedID:16753576AMP-activatedproteinkinaseactivatorA-769662isaninhibitoroftheNa(+)-K(+)-ATPase.
BenzianeBetal(2009)AmJPhysiolCellPhysiol297(6):C1554-66.PubMedID:19828836BeyondAICAriboside:insearchofnewspecificAMP-activatedproteinkinaseactivators.
GuigasBetal(2009)IUBMBLife61(1):18-26.PubMedID:18798311
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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