Hello Bio/Anisomycin/HB2239/50mg
市场价：
¥3744.00
美元价：
2880.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameAnisomycin
- ShortdescriptionProteinsynthesisinhibitor.PotentJNK/p38MAPKactivator.
- BIOLOGicaldescription
ProteinsynthesisinhibitorwhichpreventselongationandcausespolysomestABIlizationbybindingtothe60Sribosomalsubunittopreventpeptidebondformation.
AlsoactsasapotentJNKandp38MAPKactivator.
Initiatesintracellularsignalsforrapidinductionofimmediate-early(IE)genes(e.g.c-fos,fosB,c-jun,JunBandJunD).
Additionally,thoughttoblocklatelong-termpotentiation(L-LTP)andathighdosesreducesneuronalactivity. - AlternativenamesANI|Flagecidin
- BiologicalactionAntibiotic
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol3-acetate
- MolecularWeight265.31
- MolecularFormulaC14H19NO4
- CASNumber22862-76-6
- PubChemidentifier253602
- SMILESCC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O
- InChiKeyYKJYKKNCCRKFSL-RDBSUJKOSA-N
- MDLnumberMFCD00077650
- AppearanceWhitetooff-white
StoringandUsingYourProduct
- Storageinstructions+4°C;
- SolubilityoverviewSolubleinethanol(50mM)andDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAnisomycin
Anisomycinselectivelydesensitizessignallingcomponentsinvolvedinstresskinaseactivationandfosandjuninduction.
Hazzalinetal(1998)MolCellBiol.18(4):1844-54.PubMedID:9528756Theproteinsynthesisinhibitoranisomycininducesmacrophageapoptosisinrabbitatheroscleroticplaquesthroughp38mitogen-activatedproteinkinase.
Croonsetal(19286921)JPharmacolExpTher329(3):856-64PubMedID:19286921EffectsofanisomycinonLTPinthehippocampalCA1:long-termanalysisusingopticalrecording.
Mochidaetal(2001)Neuroreport12(5):987-91PubMedID:11303774
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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