Hello Bio/Puromycin dihydrochloride/HB4041/1g
市场价：
¥15132.00
美元价：
11640.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePuromycindihydrochloride
- ShortdescriptionProteinsynthesisinhibitor.Cellcultureselectionantibiotic.
- BIOLOGicaldescription
Aminonucleosideantibiotic.whichdisruptspeptidetransferonribosomesonbothprokaryoticandeukaryoticribosomestocauseprematurechainterminationduringtranslation.
Inhibitsproteintransportofintothemitochondria.
Alsoinducesapoptosisandshowsantineoplasticandantibacterialactivity.
Widelyusedasaselectionantibioticincellculture.PuromycinallowstheselectionofcellsthatcontainthepuromycinN-acetyl-transferasegene(PAC)resistancegene.
- BiologicalactionAntibiotic
- ApplicationsCellCulture,SelectionAgent
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3"-[?-Amino-p-methoxyhydrocinnamamido]-3"-deoxy-N,N-dimethyladenosinedihydrochloride
- MolecularWeight544.43
- MolecularFormulaC22H29N7O5.2HCl
- CASNumber58-58-2
- PubChemidentifier443311
- SMILESCN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
- InChiKeyRXWNCPJZOCPEPQ-VJWOANPKSA-N
- MDLnumberMFCD00012691
- AppearanceWhitetooff-white
StoringandUsingYourProduct
- Storageinstructions-20°C;
- SolubilityoverviewSolubleinDMSO(100mM)andwater(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPuromycindihydrochloride
PuromycininhibitsproteinimportintomitochondriabyinterferingwithanintramitochondrialATP-dependentreaction.
PriceandVerner(1993)BiochimBiophysActa.1150(1):89-97PubMedID:8334141Complexesbetweennascentpolypeptidesandtheirmolecularchaperonesinthecytosolofmammaliancells.
Eggersetal(1997)MolBiolCell8(8):1559-73PubMedID:9285825DipeptidylarylamidaseIIofthepituitary.Propertiesoflysylalanyl-beta-naphthylamidehydrolysis:inhibitionbycations,distributionintissues,andsubcellularlocalization.
McDonaldetal(1968)JBiolChem243(8):2028-37PubMedID:5646493
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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