你好Bio/TC-H 106/HB1400/50mg
市场价：
¥12987.00
美元价：
9990.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTC-H106
- ShortdescriptionSelectiveclassIHDACinhibitor
- BIOLOGicaldescriptionSelectiveclassIhistonedeacetylase(HDAC)inhibitor.InhibitsHDAC1,HDAC3,HDAC2andHDAC8(IC50valuesare150,370,760and5000nMrespectively).Showsslowtight-bindinginhibitionofHDAC1,2and3.Showsactionsagainstneurodegenerativediseases.Blood-brainbarrierpermeable.
- AlternativenamesHistoneDeacetylaseInhibitorVII;PimelicDiphenylamide106
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide
- MolecularWeight339.43
- Chemicalstructure
![TC-H 106 [937039-45-7]](images/hellobio/201710/hb1400.png "TC-H 106 [937039-45-7]")
- MolecularFormulaC20H25N3O2
- CASNumber937039-45-7
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTC-H106
Pimelicdiphenylamide106isaslow,tight-bindinginhibitorofclassIhistonedeacetylases.
ChouCJetal(2008)JBiolChem283(51):35402-9.PubMedID:18953021Chemicalprobesidentifyaroleforhistonedeacetylase3inFriedreich"sataxiagenesilencing.
XuCetal(2009)ChemBiol16(9):980-9.PubMedID:19778726HDACinhibitorscorrectfrataxindeficiencyinaFriedreichataxiamousemodel.
RaiMetal(2008)PLoSOne3(4):e1958.PubMedID:18463734
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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