你好Bio/Tamoxifen/HB0601/100mg
市场价：
¥1014.00
美元价：
780.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTamoxifen
- ShortdescriptionEstrogenreceptorantagoNIST/partialagonist
- BIOLOGicaldescriptionEstrogenreceptorantagonistandalsopartialagonist.AlsopotentchloridechannelHSV-1inhibitor.Bloodbrainbarrierpermeable.Inhibitstumorgrowthandinducesapoptosisinbreastcancercells.Selectivelyinhibitssterolbiosynthesis(IC50=1000nM).Showsneuroprotectivepotential.
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
- MolecularWeight371.52
- Chemicalstructure
![Tamoxifen [10540-29-1]](images/hellobio/201710/hb0601_2.png "Tamoxifen [10540-29-1]")
- MolecularFormulaC26H29NO
- CASNumber10540-29-1
- PubChemidentifier2733526
- SMILESCC/C(=C(C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3
- InChiInChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
- InChiKeyNKANXQFJJICGDU-QPLCGJKRSA-N
- MDLnumberMFCD00010454
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTamoxifen
TamoxifeninhibitsinwardrectifierK+2.xfamilyofinwardrectifierchannelsbyinterferingwithphosphatidylinositol4,5-bisphosphate-channelinteractions.
Ponce-BalbuenaDetal(2009)JPharmacolExpTher331(2):563-73.PubMedID:19654266BoththeimmunosuppressantSR31747andtheantiestrogentamoxifenbindtoanemopamil-insensitivesiteofmammalianDelta8-Delta7sterolisomerase.
PaulRetal(1998)JPharmacolExpTher285(3):1296-302.PubMedID:9618436Growthinhibitionofestrogenreceptor-positiveandaromatase-positivehumanbreastcancercellsinmonolayerandspheroidculturesbyletrozole,anastrozole,andtamoxifen.
KijimaIetal(2005)JSteroidBiochemMolBiol97(4):360-8.PubMedID:16263272Inhibitionofherpessimplexvirustype1entrybychloridechannelinhibitorstamoxifenandNPPB.
ZhengKetal(2014)BiochemBiophysResCommun446(4):990-6.PubMedID:24657267
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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