Hello Bio/4-DAMP/HB1505/
市场价：
¥3607.50
美元价：
2775.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
Properties
- Chemicalname1,1-Dimethyl-4-diphenylacetoxypiperidiniumiodide
- MolecularWeight451.33
- Chemicalstructure
![4-DAMP [1952-15-4]](images/hellobio/201710/hb1505.png "4-DAMP [1952-15-4]")
- MolecularFormulaC21H26INO2
- CASNumber1952-15-4
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor4-DAMP
Differentialcouplingofmuscarinicm2andm3receptorstoadenylylcyclasesV/VIinsmoothmuscle.ConcurrentM2-mediatedinhibitionviaGalphai3andm3-mediatedstimulationviaGbetagammaq.
MurthyKSetal(1997)JBiolChem272(34):21317-24.PubMedID:9261144Theuseofamodified[3H]4-DAMPrADIoligandbindingassaywithincreasedselectivityformuscarinicM3receptorshowsthatcorticalCHRM3levelsarenotalteredinmooddisorders.
JeonWJetal(2013)ProgNeuropsychopharmacolBiolPsychiatry47:7-12.PubMedID:23962466Regionalbindingof4-diphenylacetoxy-N-methylpiperidinemethobromide(4-DAMP)tomuscarinicreceptorsinratbrainandcomparativeanalysisofminimumenergyconformations.
CollinsDetal(1993)NeuRochemInt22(3):237-47.PubMedID:8443567
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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