Hello Bio/ω-Conotoxin GVIA/HB1218/100μg
商品编号：
HB1218-100μg
品牌：
hellobio
市场价：
¥1287.00
美元价：
990.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Nameω-ConotoxinGVIA
- ShortdescriptionPotent,selectiveCav2.2(N-type)channelblocker
- BIOLOGicaldescriptionPeptidetoxin.Potent,selective,partiallyreversIBLeCav2.2(N-type)channelblocker(IC50=0.15nM).BindsCav2.2α1subunit(α1B).Inhibitssynapticplasticityandshowshypotensiveandbradycardicactions.
- Alternativenamesω-CTX,ω-CgTx;SNX-124
- BiologicalactionBlocker
- Purity>98%
- Netpeptidecontent73%(thispeptideissoldbygrossweight)
- SpecialrequirementsAsthisproductisatoxin,customersarerequiredtocompleteashortenduserdeclarationwhenordering.Ourcustomercareteamwillbehappytohelpyouwiththis.
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameH-Cys(1)-Lys-Ser-Hyp-Gly-Ser-Ser-Cys(2)-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys(3)-Cys(1)-Arg-Ser-Cys(2)-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys(3)-Tyr-NH2trifluoroacetatesalt
- MolecularWeight3037
- MolecularFormulaC120H182N38O43S6
- CASNumber106375-28-4
- PubChemidentifier16133838
- SMILESC[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)N1)O)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CO)CCCNC(=N)N)NC2=O)N)CCCCN)CO)O)CO)CO)CC(=O)N)O)CC7=CC=C(C=C7)O)[C@@H](C)O)CCCCN)CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)CC(=O)N)CC9=CC=C(C=C9)O)CO)O
- InChiInChI=1S/C120H182N38O43S6/c1-53(165)91-114(197)138-66(10-4-6-26-122)95(178)136-68(12-8-28-132-120(129)130)98(181)149-81(107(190)139-69(93(126)176)29-55-13-19-58(167)20-14-55)49-204-207-52-84-110(193)153-80-48-203-202-47-64(123)94(177)135-65(9-3-5-25-121)9
- InChiKeyFDQZTPPHJRQRQQ-NZPQQUJLSA-N
- MDLnumberMFCD00076620
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinwater(1mg/ml)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesforω-ConotoxinGVIA
ComplexstructuresbetweentheN-typecalciumchannel(CaV2.2)andω-conotoxinGVIApredictedviamoleculardynamics.
ChenRetal(2013)Biochemistry52(21):3765-72.PubMedID:23651160DistinctmechanismscontributetoagoNISTandsynapticallyinducedmetabotropicglutamatereceptorlong-termdepression.
Connellyetal(2011)EurJPharmacol667(1-3):160-8PubMedID:21575629Theeffectofomega-conotoxinGVIAonsynaptictransmissionwithinthenucleusaccumbensandhippocampusoftheratinvitro.
HomeandKemp(1991)BrJPharmacol103(3):1733-9PubMedID:1657265omega-Conotoxinreducesfacilitationoftransmitterreleaseatthefrogneuromuscularjunction.
Zengeletal(1993)BrainRes611(1):25-30PubMedID:8100174
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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